The Value of Labial Biopsy in the Differential Diagnosis of Sarcoidosis and Sjögren’s Sydrome and Immunohistochemical Analysis

The aim of this study was the evaluation of the value of labial biopsy in the differential diagnosis of sarcoidosis and Sjögren’s Syndrome and the value of immunohistochemical markers such as CD3, CD4, CD8, and CD20 at the immunopathogenesis. Fifteen labial salivary gland biopsies from patients affected by primary Sjögren’s syndrome, and 15 labial salivary gland biopsies from patients affected by sarcoidosis, were included in the study. In all patients, biopsies were carried out as a diagnostic procedure either for sicca syndrome or sarcoidosis. Sarcoidosis and Sjögren’s Syndrome were compared according to immunohistochemical markers. It was found that CD3 and CD4 immunreactiviy were statistically higher in sarcoidosis patients, and CD 20 immunreactivity was statistically higher in SS patients. CD8 did not show any significance between groups. We also compared labial biopsy with radiological stage, and could not find any significant correlation. When the microscopic methods are not enough to differentiate between sarcoidosis and Sjögren’s Syndrome, or when they are seen together, then obtaining the subgroups of lymphocytes with immunohistochemical methods can be helpful for diagnosis.